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Aetiology of Obesity

Fructose causes insulin resistance – Hormonal Obesity XXXII

The metabolism of excessive amounts of fructose leads to fatty liver, which is a key step in the development of insulin resistance, as we saw in our last post.  Is there evidence that consumption of fructose leads to insulin resistance?  In a word - yes. As far back as 1980, there were studies linking the...

Part V – The Phantom Menace

The link between diet and disease is discussed in this lecture. We explore how diet causes heart disease, obesity, diabetes, stroke and cancer amongst other diseases and the implications for treatment. https://www.youtube.com/watch?v=2yoOx_7MLn0 Download Lecture Slides & Notes

How to Eat: Fast and Break-Fast

Several interesting recent studies regarding meal timing that deserve some attention. The first study, part of the Adventist Health Study 2, looked at a large cohort of relatively healthy people. Adults (>30 years old) attending Seventh-Day Adventist Church completed health questionnaires every 2 years. Over 50,000 people participated, and this particular study looked at meal...

The Fed and the Fasted State

In order to understand how the body gains and loses weight, you must understand how it uses energy. The body really only exists in one of two states - the fed and the fasted state. When we eat, the hormone insulin goes up and insulin is released. Now all foods stimulate different amounts of insulin...

A New Paradigm of Insulin Resistance – T2D 13

Our current paradigm of insulin resistance is that of a lock and key. Insulin is a hormone that acts upon a hormonal receptor on a cell surface in order to have an effect.  This is often referred to as lock and key model. The lock is the insulin receptor which keeps the gates to the...

Why The First Law of Thermodynamics is Utterly Irrelevant

There are many adherents to the Calories In/ Calories Out (CICO) theory that constantly bleat about "It all comes down to the First Law of Thermodynamics". The First Law of Thermodynamics refers to a law of physics where energy cannot be created or destroyed in a closed system and is ALWAYS true. It certainly holds...

How to Fix your Broken Metabolism by doing the Exact Opposite

We saw last week with the Biggest Loser study that basal metabolism plummets when you lose weight with calorie reduction. As contestants lose weight, they burn a lot less energy - up to 800 calories per day less than before. Some of that is expected, since there is less body tissue to maintain, but nevertheless,...

Power: Fasting vs Low Carb – Fasting 26

What's the difference in power between fasting and LowCarb High Fat (LCHF)? Sometimes it feels like arguing whether Batman or Superman is more powerful (Superman, of course). But they're both superheros, and the point of both these dietary superhero regimens is to lower insulin. This stems from a rational examination about the causes of obesity and type...

Obesity – Solving the Two-Compartment Problem – Fasting 21

One of the major mistakes made by the Calories In/ Calories Out (CICO) hypothesis is the presumption that energy is stored in the body as a single compartment. They consider that all foods can be reduced to their caloric equivalent and then stored in a single compartment in the body (Calories In). The body then...

Circadian Rhythms – Fasting 19

It is sometimes useful to consider things from an evolutionary standpoint. We can look back at early humans and make some general recommendations. Granted, there is little or no proof, but the exercise is still useful and interesting. There is often great debate about whether we should be eating constantly, or occasionally. For example, some...

The Proof is in the Pudding – More Turds in the PunchBowl

Have you ever heard the phrase "The proof is in the pudding"? It is also sometimes "The proof of the pudding is in the eating." What does this mean? No matter what you think, you need to look at the results to really judge something. Suppose you think that adding chalk to a pudding recipe...

Feasts and Fasts – The Cycle of Life – Fasting part 11

Feasts are an important part of life. This is a vitally important fact to acknowledge. That is, every single important celebration is marked by feasting. Eating is a celebration of life. Any diet that does not acknowledge this fact is doomed to failure. We eat cake on our birthday. We eat holiday feasts like Thanksgiving....